Product name: Anti-HIF-2α （Hypoxia-inducible factor-2α） Specification: 100ul/200ul/1ml
Description:
HIF is a heterodimer composed of an α-subunit and a -subunit. Although HIF- is constitutively expressed, its two dimerization partners, HIF-1α and -2α, are rapidly degraded in the presence of oxygen, via the ubiquitin-proteasome system.
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
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10/31/2011
What is Warfarin metabolite 4
Product name: Warfarin metabolite 4 Molecular formulae: C18H18O4
Molecular weight: 296
Chemical abstracts number: 119465-36-0
Product discription:
Warfarin metabolite 4 is a kind of secondary metabolites.
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
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Molecular weight: 296
Chemical abstracts number: 119465-36-0
Product discription:
Warfarin metabolite 4 is a kind of secondary metabolites.
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
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10/28/2011
About Anti-Histone H1b(Histone H1.4)
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in the large histone gene cluster on chromosome 6, it is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element.
The Specification of Anti-Histone H1b(Histone H1.4) include 100ul/200ul/1ml.
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What is Anti-CXC-R3/CD183 (Chemokine receptorC-X-C chemokine receptor type 3)
Specification:100ul/200ul/1ml
Description:
Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183.
CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation.
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10/27/2011
What is cytochalasin E
cytochalasin is a group of fungal metabolites, combined with intracellular actin filaments can be cut,
combined with the end in the inhibition of actin filaments at the site of polymerization, but the
solution of the microfilament poly no significant impact, and therefore treated with cytochalasin
microfilament grid cells can destroy the structure and prevent the movement of cells that affect the
assembly of actin-specific drugs.
CAS # 36011-19-5
Molecular formula C27H31NO7
Molecular weight 481.55
Crystallization. Melting point 230 ~ 232 ℃. Toxic.
cytochalasin E for biochemical research. Motor protein in the platelet aggregation inhibitor.
content from:
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combined with the end in the inhibition of actin filaments at the site of polymerization, but the
solution of the microfilament poly no significant impact, and therefore treated with cytochalasin
microfilament grid cells can destroy the structure and prevent the movement of cells that affect the
assembly of actin-specific drugs.
CAS # 36011-19-5
Molecular formula C27H31NO7
Molecular weight 481.55
Crystallization. Melting point 230 ~ 232 ℃. Toxic.
cytochalasin E for biochemical research. Motor protein in the platelet aggregation inhibitor.
content from:
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Application of antibody
1. Immune organization and immune pathology antigens, antibodies in check, such as: the tumor antigen
test, cell apoptosis detection.
2. Check for cellular factors of fluorescence flow cytometric determination.
3. Used for clinical autoimmune disease of DuoZhong antibodies fluorescence inspection, such as: the
nuclear antibody, resisting myocardial enzymes antibodies.
4. White blood cells points antigens immunofluorescence staining.
5. Used for bacteria, viruses, syphilis helicoid, leptospira microbial antigen and antibody and testing.
content from:
http://www.metallochemistry.com
test, cell apoptosis detection.
2. Check for cellular factors of fluorescence flow cytometric determination.
3. Used for clinical autoimmune disease of DuoZhong antibodies fluorescence inspection, such as: the
nuclear antibody, resisting myocardial enzymes antibodies.
4. White blood cells points antigens immunofluorescence staining.
5. Used for bacteria, viruses, syphilis helicoid, leptospira microbial antigen and antibody and testing.
content from:
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Anti CollagenⅩ sale,buy Anti CollagenⅩ
Key Features:
0.5ml or according to test a variety of packaging needs, and provide concentrated liquid or
freeze-dried powder, containing 0.01% NaN3 preservative. β-arrestin 1 protein IgG levels in 2mg/ml.
FITC was purchased from Sigma isomer I, about 70-80ug/ml, 495nm for the maximum absorption, excitation
wavelength 525 nm.
Working concentration:
With 0.01mol / l pH7.4 PBS for 1:20-1:50 dilution.
Save: -20 ℃ can be stored for one year, to avoid repeated freezing and thawing.
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0.5ml or according to test a variety of packaging needs, and provide concentrated liquid or
freeze-dried powder, containing 0.01% NaN3 preservative. β-arrestin 1 protein IgG levels in 2mg/ml.
FITC was purchased from Sigma isomer I, about 70-80ug/ml, 495nm for the maximum absorption, excitation
wavelength 525 nm.
Working concentration:
With 0.01mol / l pH7.4 PBS for 1:20-1:50 dilution.
Save: -20 ℃ can be stored for one year, to avoid repeated freezing and thawing.
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Lactobacillus Acidophilus health effects
Adjust the intestinal flora balance, inhibit the proliferation of intestinal microbial poor.
Lactobacillus acidophilus has antagonistic effects on pathogenic microorganisms. Lactobacillus
acidophilus can secrete substances anti-biotin (acidophilus streptozotocin (acidolin), acidophilus
bacteria hormone (acidophilin), lactobacillus (1aetocidon)), on the antagonism of enteric pathogens.
Lactobacillus acidophilus and Bifidobacterium fermentation of a mixture of agents. Intake of milk
containing these two viable food is good for the digestive organs, especially for gastrointestinal
disorders in infants and some long-term oral antibiotics and patients with gastrointestinal dysfunction,
eating food containing both viable fermentation milk, you can quickly restore the normal intestinal
flora balance, inhibit the proliferation of spoilage bacteria, so a good nutritional health.
content from:
http://www.lactic-acid-bacteria.net/
Lactobacillus acidophilus has antagonistic effects on pathogenic microorganisms. Lactobacillus
acidophilus can secrete substances anti-biotin (acidophilus streptozotocin (acidolin), acidophilus
bacteria hormone (acidophilin), lactobacillus (1aetocidon)), on the antagonism of enteric pathogens.
Lactobacillus acidophilus and Bifidobacterium fermentation of a mixture of agents. Intake of milk
containing these two viable food is good for the digestive organs, especially for gastrointestinal
disorders in infants and some long-term oral antibiotics and patients with gastrointestinal dysfunction,
eating food containing both viable fermentation milk, you can quickly restore the normal intestinal
flora balance, inhibit the proliferation of spoilage bacteria, so a good nutritional health.
content from:
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About Enoxaparin sodium
Enoxaparin sodium is a dry, high purity and white powder derived from Heparin Sodium degradation by special process, than extracted and refined. It belongs to anti thrombotic pharmaceutically.
Enoxaparin sodium is a low molecular weight heparin with a high anti-Xa activity. It neither influences platelet aggregation nor binding of fibrinogen to platelet. It is used in the clinical application for prophylaxis of Venous thromboembolism disease (prevention of blood clot formation in the veins) in particular those which may be associated with orthopedic or general surgery. It is also used for the treatment of established deep vein thrombosis, with or without pulmonary embolism, treatment of unstable angina and non-Q-wave myocardial infarction, and ministered con currently with aspirin, and prevention of thrombus in the extra-corporal circulation during hemodialysis.
Enoxaparin sodium is used after knee, hip, or abdominal surgeries to prevent blood clotting. It is also used to treat existing blood clots in the lungs or in the veins.
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Enoxaparin sodium is a low molecular weight heparin with a high anti-Xa activity. It neither influences platelet aggregation nor binding of fibrinogen to platelet. It is used in the clinical application for prophylaxis of Venous thromboembolism disease (prevention of blood clot formation in the veins) in particular those which may be associated with orthopedic or general surgery. It is also used for the treatment of established deep vein thrombosis, with or without pulmonary embolism, treatment of unstable angina and non-Q-wave myocardial infarction, and ministered con currently with aspirin, and prevention of thrombus in the extra-corporal circulation during hemodialysis.
Enoxaparin sodium is used after knee, hip, or abdominal surgeries to prevent blood clotting. It is also used to treat existing blood clots in the lungs or in the veins.
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What is Anti-NGF-β
Product name:Anti-NGF-β
Specification:100ul/200ul/1ml
Description:
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture, NGF induces the formation of neurite projections and, in vivo, may stimulate the innervation of tissues. NGF plays a role in the repair, regeneration, and protection of neurons, and as such could serve as a therapeutic agent in neurodegenerative conditions such as Alzheimer's disease. NGF enhances survival, growth, neurotransmitter biosynthesis of sympathetic and sensory neurons; neurotrophic factor; cutaneous innervation; growth, differentiation and survival of B lymphocytes. It also has a possible role in allergy and tissue repair. NGF is found in the hypothalamus, pituitary, thyroid gland, testes, epididymis, vascular smooth muscle cells, fibroblasts, mast cells and eosinophils. NGF is upregulated by glutamate, vitamin D3, IL6, FGF basic, astrocyte specific IL1, TNF alpha, PDGF and TGF beta. It is downregulated by GABAergic neuronal activity, glucocorticoids and Schwann cell-specific TGF beta.
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Specification:100ul/200ul/1ml
Description:
Nerve growth factor (NGF) is one of a family of neurotrophins that induce the survival and proliferation of neurons. In cell culture, NGF induces the formation of neurite projections and, in vivo, may stimulate the innervation of tissues. NGF plays a role in the repair, regeneration, and protection of neurons, and as such could serve as a therapeutic agent in neurodegenerative conditions such as Alzheimer's disease. NGF enhances survival, growth, neurotransmitter biosynthesis of sympathetic and sensory neurons; neurotrophic factor; cutaneous innervation; growth, differentiation and survival of B lymphocytes. It also has a possible role in allergy and tissue repair. NGF is found in the hypothalamus, pituitary, thyroid gland, testes, epididymis, vascular smooth muscle cells, fibroblasts, mast cells and eosinophils. NGF is upregulated by glutamate, vitamin D3, IL6, FGF basic, astrocyte specific IL1, TNF alpha, PDGF and TGF beta. It is downregulated by GABAergic neuronal activity, glucocorticoids and Schwann cell-specific TGF beta.
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10/26/2011
About Actinomucor
Sporangia of Actinomucor are more or less globose, walls of terminal sporangia are deliquescent or persistent but secondary sporangia have persistent walls, wall covered with calcium oxalate crystals, split to release spores borne on the apex of the sporangiophore or its main branches, smaller sporangia often formed on short, verticellately arranged branchlets that arise a short distance below the terminal sporangium. Stolons and rhizoids formed.
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What is Ubenimex
Ubenimex, also known as bestatin, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, aminopeptidase N. It is being studied for use in the treatment of acute myelocytic leukemia.
CAS No. 58970-76-6
Appearance: white crystalline powder
Synonyms: Bestatin; [S-(R*,S*)]-N-(3-Amino-2-hydroxy-1-oxo-4-phenylbuty1)-L-leucine
Molecular Formula C16H24N2O4
Molecular Weight 308.38
EINECS 261-529-2
Melting point 245°C.
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CAS No. 58970-76-6
Appearance: white crystalline powder
Synonyms: Bestatin; [S-(R*,S*)]-N-(3-Amino-2-hydroxy-1-oxo-4-phenylbuty1)-L-leucine
Molecular Formula C16H24N2O4
Molecular Weight 308.38
EINECS 261-529-2
Melting point 245°C.
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Cobalt salts series sale
Cobalt carbonate
Molecular formula: CoCO3
Appearance: gray-red powder, soluble in dilute acid and ammonia solution, insoluble in cold water, hot water decomposition.
Uses: battery materials, feed additives, cobalt pigments, ceramic colorants, raw cobalt salt catalyst.
Cobalt oxide
Molecular formula: CoO
Molecular weight: 74.93
Appearance: gray powder.
Purposes: for paint pigments, ceramic glazes and cobalt catalysts
Cobalt sulfate
Molecular formula: CoSO4.7H20
Molecular Weight: 281.10
Characteristics: pale brown crystals, soluble in water, slightly soluble in ethanol, in the air easily weathered.
Uses: Mainly used in battery and glass enamel coloring. System of cobalt compounds, coatings industry as paint driers.
Cobalt chloride
Molecular formula: CoCl2.6H2O
Molecular Weight: 182.98
Appearance: red or purple crystals, soluble in water.
Uses: used in electroplating, paint driers, ammonia absorption.
Molecular formula: CoCO3
Appearance: gray-red powder, soluble in dilute acid and ammonia solution, insoluble in cold water, hot water decomposition.
Uses: battery materials, feed additives, cobalt pigments, ceramic colorants, raw cobalt salt catalyst.
Cobalt oxide
Molecular formula: CoO
Molecular weight: 74.93
Appearance: gray powder.
Purposes: for paint pigments, ceramic glazes and cobalt catalysts
Cobalt sulfate
Molecular formula: CoSO4.7H20
Molecular Weight: 281.10
Characteristics: pale brown crystals, soluble in water, slightly soluble in ethanol, in the air easily weathered.
Uses: Mainly used in battery and glass enamel coloring. System of cobalt compounds, coatings industry as paint driers.
Cobalt chloride
Molecular formula: CoCl2.6H2O
Molecular Weight: 182.98
Appearance: red or purple crystals, soluble in water.
Uses: used in electroplating, paint driers, ammonia absorption.
aspyrone physical properties, chemical properties
CAS: 17398-00-4
Molecular formula: C9H12O4
Molecular Weight: 184.1892
Density: 1.313g/cm3
Boiling Point: 383.5 ° C at 760 mmHg
Flash point: 159.3 ° C
Vapor Pressure: 1.85E-07mmHg at 25 ° C
Lleida, Spain Research Center has found that ochratoxin metabolites Aspyrone prevention and treatment of
citrus brown metabolites aspyrone other Phytophthora pathogens effectively.
Molecular formula: C9H12O4
Molecular Weight: 184.1892
Density: 1.313g/cm3
Boiling Point: 383.5 ° C at 760 mmHg
Flash point: 159.3 ° C
Vapor Pressure: 1.85E-07mmHg at 25 ° C
Lleida, Spain Research Center has found that ochratoxin metabolites Aspyrone prevention and treatment of
citrus brown metabolites aspyrone other Phytophthora pathogens effectively.
Leptospira ELISA Kit use instructions
1. In the storage and incubation process avoid exposure to strong light will reagents. All reagent
bottle caps must cover tightly to prevent evaporation and pollution, reagent avoid microbial pollution
by, because proteolytic enzymes interference will lead to wrong results.
2. Be careful drain reagent and strictly abide by the given incubation time and temperature. Please note
that the specimen from the standard /, enzyme combined or substrate, the first hole and the last hole
and the time interval between the sample if too big, will lead to different "advance incubation" time,
which obviously affect the accuracy of the measurement values and repeatability. And, washing not fully
will influence test results.
3. Kit save, part of the reagents store in 20 ℃-part of the reagents store in 2-8 ℃, specific to
label) on the shall prevail.
4. There will be a strong final twist salting-out, diluted in water heating can help to dissolve.
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bottle caps must cover tightly to prevent evaporation and pollution, reagent avoid microbial pollution
by, because proteolytic enzymes interference will lead to wrong results.
2. Be careful drain reagent and strictly abide by the given incubation time and temperature. Please note
that the specimen from the standard /, enzyme combined or substrate, the first hole and the last hole
and the time interval between the sample if too big, will lead to different "advance incubation" time,
which obviously affect the accuracy of the measurement values and repeatability. And, washing not fully
will influence test results.
3. Kit save, part of the reagents store in 20 ℃-part of the reagents store in 2-8 ℃, specific to
label) on the shall prevail.
4. There will be a strong final twist salting-out, diluted in water heating can help to dissolve.
more about:
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what is Tacrolimus
Tacrolimus is FK506, is extracted from a soil fungus macrolide antibiotic, has strong immunosuppressive
properties, is the strength of its drug cyclosporin A, 10-100 times, arise prevention of organ
transplant rejection is better than cyclosporine.
Tacrolimus is only applied to the clinical history of more than ten years, the time is shorter.
Therefore, in some respects (Pharmacology and Toxicology) study is not comprehensive enough. The main
side effects of Tacrolimus nephrotoxicity, neurotoxicity, and circulatory system, digestive system,
respiratory system and cardiovascular system function. Tacrolimus can induce diabetes (odds of about 10%
to 30%), can cause severe ketoacidosis. Tacrolimus-related incidence of hypertension than CsA
significantly reduced. Tacrolimus and CsA with rapamycin compared with rapamycin is a calmodulin does
not interact with the new immunosuppressive agents, is considered to have no effect on blood pressure.
Immunosuppressant macrolides (including FK506 and rapamycin, etc.) not only orally, but also for
external use, mainly for some skin diseases such as atopic dermatitis, psoriasis, lichen planus, contact
dermatitis and bald spots, etc. have a certain effect. In addition, "Arthritis and Rheumatism" magazine
(Arthritis Rheum 2003; 48:3328-3337) 12, says a report released last month, immunosuppressant tacrolimus
in 2 or 3mg / day dose of a single treatment of active rheumatoid arthritis (RA) appears safe and
effective, but usually larger doses greater improvements.
properties, is the strength of its drug cyclosporin A, 10-100 times, arise prevention of organ
transplant rejection is better than cyclosporine.
Tacrolimus is only applied to the clinical history of more than ten years, the time is shorter.
Therefore, in some respects (Pharmacology and Toxicology) study is not comprehensive enough. The main
side effects of Tacrolimus nephrotoxicity, neurotoxicity, and circulatory system, digestive system,
respiratory system and cardiovascular system function. Tacrolimus can induce diabetes (odds of about 10%
to 30%), can cause severe ketoacidosis. Tacrolimus-related incidence of hypertension than CsA
significantly reduced. Tacrolimus and CsA with rapamycin compared with rapamycin is a calmodulin does
not interact with the new immunosuppressive agents, is considered to have no effect on blood pressure.
Immunosuppressant macrolides (including FK506 and rapamycin, etc.) not only orally, but also for
external use, mainly for some skin diseases such as atopic dermatitis, psoriasis, lichen planus, contact
dermatitis and bald spots, etc. have a certain effect. In addition, "Arthritis and Rheumatism" magazine
(Arthritis Rheum 2003; 48:3328-3337) 12, says a report released last month, immunosuppressant tacrolimus
in 2 or 3mg / day dose of a single treatment of active rheumatoid arthritis (RA) appears safe and
effective, but usually larger doses greater improvements.
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