About Anti-HIF-2α （Hypoxia-inducible factor-2α）

　　Product name:  Anti-HIF-2α （Hypoxia-inducible factor-2α）　　Specification:  100ul/200ul/1ml
　　Description:
　　HIF is a heterodimer composed of an α-subunit and a -subunit. Although HIF- is constitutively expressed, its two dimerization partners, HIF-1α and -2α, are rapidly degraded in the presence of oxygen, via the ubiquitin-proteasome system.
　　Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
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