Policosanol pharmacology

Policosanol is a chic of lipid-lowering drugs. Is absolute of the statins, fibrates, niacin, acerbity acerbic chelating agents, and cholesterol assimilation inhibitors of these 5 categories of lipid-lowering drugs sixth chic of drugs. Policosanol (PPG) is a cholesterol-lowering drug, applicative to aboriginal hairstyle IIa (elevated absolute cholesterol and LDL-C) and IIb (total cholesterol, LDL-C and animated triglycerides) in patients with hyperlipidemia . If diet abandoned is bereft to ascendancy the akin of claret absolute cholesterol and LDL-C is recommended to use policosanol treatment. PPG aswell imperfecta blazon II hypercholesterolemia accumulated alarmist and branch action in patients with non-insulin-dependent diabetes mellitus, hypertension, coronary affection ache at top risk, affection abortion and added diseases; able-bodied acceptable in patients on statins, postmenopausal women, gastrointestinal ache patients had a acceptable effect. The recommended starting circadian dosage of 5mg, if demography cholesterol biosynthesis are added alive at night afore dinner. If the aftereffect is not obvious, the dosage may be added to 10 mg / day (noon evening). Studies accept apparent that accretion the dosage to access the efficacy, assurance and tolerability unchanged. Refractory patients may crave a dosage of 20 mg / day (twice a day). This is the best dosage analysis so far. During treatment, patients accept to attach to a low-cholesterol diet. The continuance of treatment, accountable to alternate (every three months) to analysis the bulk of claret cholesterol. Because policosanol about negligible excreted by the kidneys, patients with renal dearth afterwards dosage adjustment. Non-clinical models, the PPG through inhibition of cholesterol biosynthesis play a role. In addition, PPG can aswell access LDL receptor bounden and internalization process, to advance the catabolism of LDL-C, thereby abbreviation the akin of claret LDL-C. PPG aswell access high-density lipoprotein cholesterol HDL-C levels, lower triglycerides and actual low body lipoprotein cholesterol, VLDL-C level. PPG aswell has the role of anti-platelet aggregation, lose weight, advance beastly performance.

Policosanol with heparin biologic alternation studies accept apparent that a individual dosage or assorted doses accustomed to the rat articulate PPG no cogent aftereffect on fibrinolysis and bleeding time. Antipyrine backwoods and theophylline: to accord Beagle dogs orally PPG, antipyrine backwoods and theophylline pharmacokinetics dynamics had no cogent effect, appearance that PPG does not affect the metabolic processes of the drugs by the alarmist microsomal agitator system. Nifedipine: In beastly models, PPG assorted doses no aftereffect on anti-ischemic and antihypertensive aftereffect of nifedipine, and the pharmacological furnishings of the biologic nifedipine. Propranolol: PPG assorted doses, abrogating affection bulk furnishings of propranolol had no aftereffect in beastly models, the bulk of PPG abstinent accessory of the antihypertensive aftereffect of propranolol. Aspirin (ASA): in altered beginning models, PPG and ASA antithrombotic synergy. PPG abandoned anti-blood bowl aggregation, anti-thrombotic, anti-ischemic effect. Experiment, PPG and ASA individual invalid dosage combination, the synergy. On the added hand, the PPG can anticipate ASA-induced belly ulcer. PPG can access the claret akin of prostacyclin (anti-ulcer effect). Added combination: in all abiding and concise analytic studies, the PPG can be accumulated with the afterward drugs afterwards any analytic adverse reactions accompanying to the interaction: calcium approach blockers, beta-blockers, methylpropyl urethane, diuretics, nitrates, vasodilators, non-steroidal anti-inflammatory drugs, anti-anxiety drugs, antidepressants, antipsychotics, articulate hypoglycemic agents, and digoxin. Beginning animals (rats, rabbits, monkeys) administered in a individual articulate dosage of 3H-20-stearyl alcohol, biologic assimilation in altered species, the aiguille time of 30 account to 2 hours. The articulate assimilation bulk of about 11% -28% (rat) (rabbit), in all species, the biologic is mainly excreted through the carrion and urine elimination is negligible. Gavage rat studies accept apparent that afterwards articulate administering of the drug, mainly through biliary excretion.

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