Mycophenolic acid (MPA) Introduction

Mycophenolic acid (MPA) is an immunosuppressive abettor accessible either as an ester prodrug or as a sodium salt. Mycophenolate mofetil (MMF) is the 2-morpholinoethyl ester prodrug of MPA formulated to advance its bioavailability. Mycophenolate sodium is a delayed absolution conception that delivers MPA in the baby civil after getting appear into the stomach. MPA is adumbrated as antibacterial abettor in patients accepting allogeneic renal, cardiac or hepatic transplants. It is a noncompetitive, careful and capricious inhibitor of inosine monophosphate dehydrogenase (IMPDH). IMPDH is an important rate-limiting agitator complex in purine synthesis, which converts inosine monophosphate (IMP) to guanosine monophosphate.

Mycophenolic acid is a potent, selective, uncompetitive, and capricious inhibitor of inosine monophosphate dehydrogenase (IMPDH), and accordingly inhibits the de novo alleyway of guanosine nucleotide amalgam after assimilation into DNA. Because T- and B-lymphocytes are alarmingly abased for their admeasurement on de novo amalgam of purines, admitting added corpuscle types can advance deliver pathways, mycophenolic acid has almighty cytostatic furnishings on lymphocytes. Mycophenolic acid inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. Addition of guanosine or deoxyguanosine reverses the cytostatic furnishings of mycophenolic acid on lymphocytes. Mycophenolic acid aswell suppresses antibiotic accumulation by B-lymphocytes. Mycophenolic acid prevents the glycosylation of lymphocyte and monocyte glycoproteins that are complex in intercellular adherence to endothelial beef and may arrest application of leukocytes into sites of deepening and affix rejection.