Ascomycin description

CAS No.: 11011-38-4

Molecular Formula: C43H69NO12

Molecular Weight: 792.01

Ascomycin is a macrolide immunosuppressant antibacterial and an analog of the acclaimed antibacterial FK506. Ascomycin binds to the FK-506-binding protein FKBP12 and blocks the peptidyl-prolyl cis-trans isomerase action of the protein. This binded circuitous aswell inhibits the action of calcineurin, appropriately suppressing the presentation of Th1 and Th2-type cytokines in beef and abbreviation assembly of interleukins IL-2, 4, and 10, arch to immunosuppression. Pimecrolimus (sc-208172), a acquired of the Ascomycin macrolide, has been apparent to block the absolution of allergic acknowledgment mediators from mast cells.