Product name: Anti-HIF-2α （Hypoxia-inducible factor-2α） Specification: 100ul/200ul/1ml
Description:
HIF is a heterodimer composed of an α-subunit and a -subunit. Although HIF- is constitutively expressed, its two dimerization partners, HIF-1α and -2α, are rapidly degraded in the presence of oxygen, via the ubiquitin-proteasome system.
Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-2 alpha is predominantly expressed in highly vascularized tissues of adult humans and endothelial cells of the embryonic and adult mouse, whereas HIF-1alpha functions primarily in extravascular tissues. HIF-2 alpha is also a potent activator of the tie-2 gene, which is known to be selectively expressed in endothelial cells.
More about : buy Anti-HIF-2α （Hypoxia-inducible factor-2α）
10/31/2011
What is Warfarin metabolite 4
Product name: Warfarin metabolite 4 Molecular formulae: C18H18O4
Molecular weight: 296
Chemical abstracts number: 119465-36-0
Product discription:
Warfarin metabolite 4 is a kind of secondary metabolites.
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
Read more:buy Warfarin metabolite 4
Molecular weight: 296
Chemical abstracts number: 119465-36-0
Product discription:
Warfarin metabolite 4 is a kind of secondary metabolites.
The metabolism of the clinically utilized, anticoagulant warfarin [4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one] by rat liver microsomes has been investigated. The structure of a new warfarin metabolite [4-hydroxy-3-(3-oxo-1-phenyl-1-butenyl)-2H-1-benzopyran-2-one] (dehydrowarfarin) has been determined by mass spectral comparison with the chemically synthesized compound. The formation of dehydrowarfarin is catalyzed by cytochrome P-450 and is unusual in that the final product is effectively dehydrogenated warfarin.
Read more:buy Warfarin metabolite 4
10/28/2011
About Anti-Histone H1b(Histone H1.4)
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is found in the large histone gene cluster on chromosome 6, it is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element.
The Specification of Anti-Histone H1b(Histone H1.4) include 100ul/200ul/1ml.
More about: buy Anti-Histone H1b(Histone H1.4)
What is Anti-CXC-R3/CD183 (Chemokine receptorC-X-C chemokine receptor type 3)
Specification:100ul/200ul/1ml
Description:
Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183.
CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation.
Read more: buy Anti-CXC-R3/CD183 (Chemokine receptorC-X-C chemokine receptor type 3)
订阅：
博文 (Atom)