Tryptophol biological effects

Tryptophol and its derivatives 5-hydroxytryptophol and 5-methoxytryptophol, abet beddy-bye in mice. It induces a sleep-like accompaniment that lasts beneath than an hour at the 250 mg/kg dose. These compounds may play a role in physiological beddy-bye mechanisms. It may be a anatomic analog of serotonin or melatonin, compounds complex in beddy-bye regulation.

Tryptophol shows genotoxicity in vitro.

Tryptophol is a quorum analysis atom for the aggrandize Saccharomyces cerevisiae. It is aswell begin in the bloodstream of patients with abiding trypanosomiasis. For that reason, it may be a quorum analysis atom for the trypanosome parasite.

In the case of trypanosome infection, tryptophol decreases the allowed acknowledgment of the host.

As it is formed in the alarmist afterwards booze assimilation or disulfiram treatment, it is aswell associated with the abstraction of alcoholism. Pyrazole and booze accept been apparent to arrest the about-face of exogenous tryptophol to indole-3-acetic acerbic and to potentiate the anesthetic hypothermic furnishings of tryptophol in mice.

It is a advance apostle of cucumber hypocotyl segments. The auxinic activity in agreement of antecedent accumulation is even bigger for tryptophol arabinoside on Cucurbita pepo hypocotyl fragments.