What is Lp-a ELISA Kit

　　Product name:  Lp-a ELISA Kit　　
        Advantages:  Calibrated against a highly purified, fully validated
　　Storage:  Store all components at 2-8 degree Celsius with the exception of the standard, which should be stored frozen.
　　Description:　　Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein particle formed by assembly of LDL particles and apo(a) bound to apoB-100 component of LDL . Apo(a) is the main constituent of Lp(a), has serine proteinase activity and is able of autoproteolysis . Apo(a) has 4548 amino acids, variable sizes from 200 to 700 kDa, multiple isoforms, and structural homology with plasminogen . It competes with plasminogen for its binding site, inhibiting tissue-type plasminogen activator 1 and leading to reduced fibrinolysis . The mean Lp(a) protein level ranged from 78 to 175 μg/ml depending on populations and the risk threshold is 300 μg/ml. High level of Lp(a) in blood is a risk factor for myocardial infarction (MI), coronary heart disease (CHD), cerebrovascular disease (CVD), atherosclerosis, thrombosis, and stroke .
　　Immunoassay for quantitative determination of human lipoprotein(a) in serum or plasma.
　　Dilute each serum or plasma specimen to be tested 1:400 with the Lp(a) specimen diluents provided. (Serum specimens with high Lp(a) levels should be diluted more than 1:400 for accurate Lp(a) determination.) A pre-dilution using PBS (phosphate buffer) may be done followed by a final dilution in specimen diluents to bring the serum or plasma final dilution to 1:400.
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