Maslinic acid description

CAS Number:      4373-41-5

Molecular Weight:     472.7

Molecular Formula:    C30H48O4

Solubility:      Soluble in water (0.3 mg/ml at 25 °C), ethanol (~0.5 mg/ml), DMSO (~20 mg/ml), DMF (~15 mg/ml), and 1: 2 solution of ethanol : PBS (pH 7.2) (~0.3 mg/ml).

Storage:   Store at -20° C

Melting Point:   241.38 °C (Predicted)

Boiling Point:   569.97 °C at 760 mmHg (Predicted)

Density:   1.15 g/cm3 (Predicted)

Maslinic acid is begin in a amount of accustomed sources, a lot of conspicuously pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative abettor adjoin Caco-2 blight beef (EC50 = 15 µM), HT-29 animal colon blight beef (EC50 = 74 µM), 1321N1 astrocytoma beef (IC50 = 25 µM), and animal leukemia (CCRF-CEM and CEM/ADR5000) beef (IC50 = 7 µM and 9 µM respectively).Maslinic acid • s antiproliferative action acceptable comes from the consecration of an oxidative apoptotic pathway, causing corpuscle aeon and cytoskeleton alterations. Maslinic acid has been begin to abate intracellular oxidative accent via inhibition of NO and H2O2 assembly and abridgement of pro-inflammatory cytokine bearing in murine macrophages. Recently maslinic acid has been begin to arrest the advance of the HIV virus by inhibiting the archetype of a primary HIV-1 abstract as able-bodied as decreased the cytopathic aftereffect and p24 antigen levels in MT2 cells.