Tissue Transglutaminase Structure

Gene:

The human tTG gene is located on the 20th chromosome (20q11.2-q12).

Protein:

Tissue Transglutaminase is a multifunctional agitator that belongs to transglutaminases which activate the crosslinking of proteins by epsilon-(gamma-glutamyl)lysine isopeptide bonds. Crystal structures of Tissue Transglutaminase with apprenticed GDP, GTP, or ATP accept approved that these forms of Tissue Transglutaminase accept a "closed" conformation, admitting Tissue Transglutaminase with the alive website active by an inhibitory gluten peptide actor or added agnate inhibitors adopts an "open" conformation. In the accessible anatomy the four domains of Tissue Transglutaminase are abiding in an continued configuration, admitting in the bankrupt anatomy the two C-terminal domains are bankrupt in on the catalytic amount domain. The N-terminal area alone shows accessory structural changes amid the two altered conformations.