Description of Isosorbide mononitrate

Isosorbide mononitrate is a biologic acclimated principally in the analysis of angina pectoris1 and acts by dilating the claret argosy so as to abate the claret pressure. It is awash by AstraZeneca beneath the barter name Imdur.

Isosorbide mononitrate is acclimated to for the the antibacterial analysis of angina pectoris; that is, it is taken in adjustment to anticipate or at atomic abate the accident of angina. Research on Isosorbide mononitrate as a cervical ripener to abate time at hospital to bearing is supportive.

Isosorbide mononitrate is an alive metabolite of isosorbide dinitrate and exerts qualitatively agnate effects. Isosorbide mononitrate reduces the workload of the affection by bearing venous and arterial dilation. By abbreviation the end diastolic burden and volume, isosorbide mononitrate lowers civil pressure, appropriately arch to an advance in the subendocardial claret flow. The net aftereffect if administering isosorbide mononitrate is accordingly a bargain workload for the affection and an advance in the oxygen supply/demand antithesis of the myocardium.

The adverse reactions which chase accept been appear in studies with isosorbide mononitrate:

Very common. Headache predominates (up to 30%) necessitating abandonment of 2 to 3 % of patients, but the accident reduces rapidly as analysis continues .

Common. Tiredness, beddy-bye disturbances (6%) and gastrointestinal disturbances (6%) accept been appear during analytic trials with isosorbide mononitrate adapted absolution tablets, but at a abundance no greater than for placebo. Hypotension (4 to 5%), poor appetence (2.5%), abhorrence (1%).