CD163,
aswell appointed M130, is a macrophage-associated antigen that is a affiliate
of the scavenger receptor cysteine-rich (SRCR) superfamily. It is awful bidding
on macrogphages and to a bottom admeasurement on monocytes. The astute
phase-regulated and signal-inducing macrophage protein, CD163, is a receptor
that scavenges claret by mediating endocytosis of haptoglobin-hemoglobin
complexes. CD163 binds alone haptoglobin and claret in complex, which indicates
the acknowledgment of a receptor-binding neoepitope. The receptor-ligand
alternation is calcium-dependent and of top affinity. The actuality of several
CD163 isoforms, which alter in the anatomy of their cytoplasmic domains and
accepted phosphorylation sites, suggests that these isoforms aswell alter in
their signaling mechanism. The gene which encodes CD163 maps to animal
chromosome 12p13.31.
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