Leflunomide Mechanism of Action

Leflunomide is an immunomodulatory biologic that achieves its furnishings by inhibiting the mitochondrial agitator dihydroorotate dehydrogenase (DHODH), which plays a key role in the de novo amalgam of uridine monophosphate (rUMP), which is appropriate for the amalgam of DNA and RNA. Hence, leflunomide inhibits the reproduction of rapidly adding cells, abnormally lymphocytes.

The inhibition of animal DHODH by teriflunomide, the active metabolite of leflunomide, occurs at levels (approximately 600 nM) that are accomplished during analysis of rheumatoid arthritis (RA). Teriflunomide aswell inhibits several tyrosine kinases.Teriflunomide prevents the amplification of activated and autoimmune lymphocytes by interfering with their corpuscle aeon progression while nonlymphoid beef are able to use addition alleyway to accomplish their ribonucleotides by use of deliver pyrimidine pathway, which makes them beneath abased on de novo synthesis. Teriflunomide aswell has antiviral furnishings adjoin abundant bacilli including CMV, HSV1 and the BK virus, which it achieves by inhibiting viral archetype by interfering with nucleocapsid tegumentation and appropriately virion assembly.