CAS:
23541-50-6
Molecular
Formula: C27H29NO10.HCl
Molecular
Weight: 563.99
Daunorubicin Hydrochloride is rapidly and broadly broadcast in tissues, with accomplished
levels in the spleen, kidneys, liver, lungs, and heart. The biologic binds to
abounding cellular components, decidedly nucleic acids. There is no affirmation
that Daunorubicin Hydrochloride crosses the blood-brain barrier, but the
biologic calledly crosses the placenta.
Daunorubicin
Hydrochloride is abundantly metabolized in the alarmist and added tissues,
mainly by cytoplasmic aldo-keto reductases, bearing daunorubicinol, the above
metabolite which has antineoplastic activity. Approximately 40% of the biologic
in the blood is present as daunorubicinol aural 30 account and 60% in 4 hours
afterwards a dosage of daunorubicin. Further metabolism via abridgement break
of the glycosidic bond, 4-O demethylation, and alliance with both sulfate and
glucuronide accept been demonstrated. Simple glycosidic break of daunorubicin
or daunorubicinol is not a cogent metabolic alleyway in man. Twenty-five
percent of an administered dosage of Daunorubicin Hydrochloride is alone in an active
anatomy by urinary elimination and an estimated 40% by biliary excretion.
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