Hyoscyamine is the 3(S)-endo isomer of
atropine.
Hyoscyamine is a belladonna alkaloid
acquired and the levorotatory anatomy of racemic atropine abandoned from the
plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic
activity. Hyoscyamine functions as a non-selective, aggressive adversary of
muscarinic receptors, thereby inhibiting the parasympathetic activities of
acetylcholine on the salivary, bronchial, and diaphoresis glands, as
able-bodied as the eye, heart, bladder, and gastrointestinal tract. These
inhibitory furnishings could cause a abatement in saliva, bronchial mucus,
belly juices, and sweat. Furthermore, its inhibitory activity on bland beef
prevents float abbreviating and decreases gastrointestinal motility.
Hyoscyamine competes agreeably with
acetylcholine for bounden at muscarinic receptors in the salivary, bronchial,
and diaphoresis glands as able-bodied as in the eye, heart, and
gastrointestinal tract. The accomplishments of hyoscyamine aftereffect in a
abridgement in salivary, bronchial, belly and diaphoresis gland secretions,
mydriasis, cycloplegia, change in affection rate, abbreviating of the float
detrusor beef and of the gastrointestinal bland muscle, and decreased
gastrointestinal motility.