New secalonic acid derivatives D69 D human breast cancer in vivo inhibitory activity

Traditional anti-cancer drugs are generally derived from natural plants and terrestrial microorganisms
land extraction, but as the decades long development of new land to be developed less and less
probability of active substances, but also increasingly difficult greater. As a result, people want to
be isolated from the marine new active substances. Since the beginning of the 1950s, with the
spectroscopy, high-throughput screening and structural analysis technology development, isolated from
marine organisms were screened as ecteinascidin-743, aplidine, bryostatin 1, and other factors rye acid
D species diversity in structure and better anti-tumor active substances. D69 is derived from a marine
Streptomyces strains isolated secondary metabolites of a compound containing the cyclic peptide lactone
ring and the five chromophore, is a new type of rye acid derivatives D . Through its potential in vivo
anti-tumor activity of research, from initial cellular and molecular level of D69 in human breast cancer
cell growth inhibition and induction of apoptosis, in order to further develop efficiency and low
toxicity of anticancer drugs lay the foundation for .
more about:
secalonic acid F
secalonic acid D
Secalonic acid B
content from:
http://nanomaterials.blog.com/2011/09/14/new-secalonic-acid-derivatives-d69-d-human-breast-cancer-in-vivo-inhibitory-activity/